Importance of C, General introduction of structure of molecules
Atomic orbitals, filling of AO, Octet rules, Types of bonds
Types of bond, electronic structure of molecules, Aos and introduction to MOT
Mot & disadvantages, VSEPR theory, Structural prediction of molecules, Methane, ethane, ethylene, acetylene using VSEPR theory
Bond Angle, Length and Energy and introduction to resonance
Resonance, Rules of resonance, Mesomeric Effect
Steric inhibition to resonance, Cross-conjugation and introduction to hyperconjugation
Hyper conjugation, Tautomerism
Tautomerism - Different types other than Keto-Enol tautomerism. H-bonding & its importance. Acid-Base concept. Introduction to Bronsted acid-base theory
Mechanism of Bronsted Acid-Base theory. Lewis theory-HSAB principle, Factor affecting Acid-base theory
Structure based relationship on acidity & basicity
Introduction- criteria for Aromatic, non-aromatic and anti-aromatic compounds, 2 and 6 electron system
Aromaticity-Other aromatic sextet, Azulene, [10] Annulenes, Anti-aromaticity- 4 electron system
Hetero aromatic system, Annellation, Partial bond fixation, Tropylium cation, Cycloheptatriene as homo-aromatic system
Anti-aromatic - 8 electron system, Aromaticity - 14 and 18 electron system
Other classes of Aromatic compounds - Mesoionic compounds, Dianion of squaric acid, Homo aromatic compounds & Fullerenes & Bucky balls, Unit 2- Reactive intermediates
Carbocation - Stability, Structure, Methods of generation
Carbocation - Reactivity, Carbanion - Stability
Carbanion - Stability, reactivity and methods of generation, Carbene - Types of carbene - Singlet and triplet carbenes, Methods of generation
Reactive Intermediates - Carbenes and Nitrenes
Reactive Intermediates - Free radicals
Reaction Mechanism - Introduction, Thermodynamic and Kinetic requirement for a chemical reaction
Kinetics Vs Thermodynamic controlled reaction & product, Hammond Postulate & Principle of microscopic reversibility
Hammett relationship - Substituent constant and reaction constant
Hammett reaction constant, Reaction where RHo is -ve and low value, Taft equation, isotope labelling in finding out whether rxn is intra or inter-molecular
Stereochemistry of bromine addition, hydrogen addition, hydroboration-oxidation reaction
Optical isomerism of compounds with N, S or P containing compounds, Geometrical isomerism - E and Z isomerism
Geometrical isomerism of cumulenes and oximes, Physical and spectral properties of geometrical isomers, Determination of configuration of geometrical isomers
Geometrical isomerism of monocyclic and fused ring systems, Atropisomerism of biphenyl - Examples.
Atropisomerismsss-Define, R, S configuration of Atropisomere, Optical activity of allenes
Allenes- R, S configuration, Spiranes - Preparations and R, S configuration, Introduction to nuceohilic substitution Reaction
Factors affecting SN1 reaction, Difference between SN1 and SN2 reaction, Reactivity of vinylic and aryl halides, Allylic and benzylic halide, Rearrangement in SN1 reaction, SNi reaction
Nucleophilic substitution at Norbornyl and bridgehead system, Neighboring group participation, Nucleophilic substitution at Carbonyl carbon
Examples of various nucleophilic substitution reactions with mechanism - Ester hydrolysis catalysed by acid and Base, Halogen exchange reaction, Alkylation & acylation of amines
Aliphatic Nucleophilic substitution - Reaction of active methylene groups - Dehalogenation, Acylation, Claisen Condensation, Dieckmann condensation,Nucleophilic Aromatic substitution reaction - Introduction
SNAr reaction, Meisenheimer complex, Benzyne mechanism, Direct & cine substitution, Chichibabin reaction, SEAr reaction - introduction
SEAr reaction, Effect of substituents on reactivity, inductive electron donation & withdrawal, electron donation & withdrawal by resonance, relative reactivity
Effect of substituents on orientation - inductive electron donating, resonance electron donating, Inductive and resonance electron withdrawing, ortho-para ratio, ortho effect
Friedel Craft's alkylation and acylation reaction - Mechanism and limitation, Vilsmeier- Haack Reaction, Gattermann-koch reaction
Electrophilic substitution reaction: Diazonium coupling, Ipso attack, SE1 and SE2 reaction, Addition reaction: Types, Electrophilic addition reaction with examples
Regioselectivity in Electrophilic addition Reaction, Markovnikov's product, Rearrangement of carbocation, Hydroboration-Oxidation reaction, Example
Hydroboration-oxidation reaction, Stereochemistry of addition reaction, Free radical addition - peroxide effect, Michael addition and Robinson annulation
Conjugate addition to alpha, beta-unsaturated carbonyl compounds- Gilmann reagent and grignard reagent, Elimination reaction - E2 reaction- Regioselectivity
Deviation from Zaitsev's rule - COnjugate alkene, Presence of alkyl fluorides, Bulky bases, E1 Reaction - Mechanism, Relative stability of alkyl halides, Carbocation rearrangement, Competition between E1 and E2 reactions, Stereochemistry of E2 reaction.
Stereochemistry of E2 elimination- Anti elimination, Stereoselectivity in E2 reaction - E Vs Z alkene stability, Stereochemistry of the E1 Reaction, Elimination from Cyclic Compounds - E1 and E2
Competition between Substitution and elimination, SN2 vs E2, SN1 vs E1, Pyrolytic elimination, Chugaev and cope elimination
Shapiro Elimination and mechanism, Hofmann exhaustive methylation and Hofmann eimination reaction - Regioselectivity.
Cram's law of asymmetric induction, Revision on elimination reaction
Revision on Aromatic substitution reaction-SNAr reaction, Benzyne mechanism, Chichibabin reaction, SEAr reaction, Effect of subn on orientation and reactivity, Ortho effect
Revision on Substitution- SEAr, and Aliphatic Nucleophilic substitution reaction
